Safety

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<p>Before answering these questions on your team Safety page, be sure to read the [https://igem.org/Safety  Safety in iGEM] page. and the FAQ section below.</p>
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<p>For iGEM 2013, teams are asked to detail how they approached any issues of biological safety associated with their projects. Specifically, teams must consider and provide answers to the questions below: </p>
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===Why does iGEM ask teams to address safety questions and screen projects? ===   
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<p>Before answering these questions on your team Safety page, be sure to read the <a href="https://igem.org/Safety" style="font-weight:bold;">Safety in iGEM</a> page. and the FAQ section below.</p>
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<p><strong>Key questions </strong></p>
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<p>For iGEM 2013, teams are asked to detail how they approached any issues of biological safety associated with their projects. Specifically, teams should consider the following questions: </p>
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    <li><strong>Would any of your project ideas raise safety issues in terms of:
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      </strong>
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        <li> researcher safety, </li>
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        <li> public safety, or </li>
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        <li> environmental safety? </li>
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      </ul>
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    </li>
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    <li><strong> Do any of the new BioBrick parts (or devices) that you made this year raise any safety issues? If yes,
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      <ul>
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        <li> did you document these issues in the Registry? </li>
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        <li> how did you manage to handle the safety issue? </li>
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        <li> How could other teams learn from your experience? </li>
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    <li><strong>Is there a local biosafety group, committee, or review board at your institution? </strong>
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            <li> If yes, what does your local biosafety group think about your project? </li>
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            <li> If no, which specific biosafety rules or guidelines do you have to consider in your country? </li>
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    <li><strong>Do you have any other ideas how to deal with safety issues that could be useful for future iGEM competitions? How could parts, devices and systems be made even safer through biosafety engineering? </strong></li>
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  <td><p>&nbsp;</p>    </td>
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<p><span class="style1">Teams, please document any answers to these safety questions on your wiki safety page. Judges will be asked to evaluate your project, in part, on the basis of if and how you considered and addressed issues of biological safety.</span> If any questions arise regarding iGEM and biological safety please send an email to safety AT igem.org. </p>
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==FAQ==
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===Question 1: Why does iGEM ask teams to address safety questions and screen projects? ===   
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iGEM safety questions and screening procedures are designed:
iGEM safety questions and screening procedures are designed:
*To protect team members as they work in their labs, iGEM institutions, the general public and the environment
*To protect team members as they work in their labs, iGEM institutions, the general public and the environment
*To encourage team members to consider safety, health, security, and environmental implications of their projects, both within and beyond the scope of iGEM competition.
*To encourage team members to consider safety, health, security, and environmental implications of their projects, both within and beyond the scope of iGEM competition.
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===Question 2: We need clarification on the safety questions. Would you please provide guidance on each iGEM safety question?===
 
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===iGEM Safety Questions===
====1. Would any of your project ideas raise safety issues in terms of:====
====1. Would any of your project ideas raise safety issues in terms of:====
*researcher safety,  
*researcher safety,  
*public safety, or  
*public safety, or  
*environmental safety
*environmental safety
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The largest threat to researchers, the public, and the environment is potential contamination by the E. Coli bacteria. If this project were to be conducted on a large scale, large quantities of the bacteria would be necessary and would therefore increase risk. Both humans and animals could be harmed by the bacteria. Fortunately, if careful measures are taken to limit exposure to the bacteria and to sanitize areas that come into contact with the bacteria, this problem can be managed. The team has not received formal training but has taken care to disinfect materials that make contact with the bacteria. Though E. Coli used in the project can be harmful, it is something that is easy to obtain, so the risk of someone with malicious intent using the bacteria would not be significantly raised. The best way in which to avoid that kind of scenario is to limit access and exposure to the bacteria, especially when there are large amounts of it.
=====Guidance:=====  
=====Guidance:=====  
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====2. Do any of the new BioBrick parts (or devices) that you made this year raise safety issues? If yes, ====
====2. Do any of the new BioBrick parts (or devices) that you made this year raise safety issues? If yes, ====
*Did you document these issues in the Registry?  
*Did you document these issues in the Registry?  

Latest revision as of 23:05, 20 June 2013

Contents

Before answering these questions on your team Safety page, be sure to read the Safety in iGEM page. and the FAQ section below.

For iGEM 2013, teams are asked to detail how they approached any issues of biological safety associated with their projects. Specifically, teams must consider and provide answers to the questions below:


Why does iGEM ask teams to address safety questions and screen projects?

iGEM safety questions and screening procedures are designed:

  • To protect team members as they work in their labs, iGEM institutions, the general public and the environment
  • To encourage team members to consider safety, health, security, and environmental implications of their projects, both within and beyond the scope of iGEM competition.


iGEM Safety Questions

1. Would any of your project ideas raise safety issues in terms of:

  • researcher safety,
  • public safety, or
  • environmental safety

The largest threat to researchers, the public, and the environment is potential contamination by the E. Coli bacteria. If this project were to be conducted on a large scale, large quantities of the bacteria would be necessary and would therefore increase risk. Both humans and animals could be harmed by the bacteria. Fortunately, if careful measures are taken to limit exposure to the bacteria and to sanitize areas that come into contact with the bacteria, this problem can be managed. The team has not received formal training but has taken care to disinfect materials that make contact with the bacteria. Though E. Coli used in the project can be harmful, it is something that is easy to obtain, so the risk of someone with malicious intent using the bacteria would not be significantly raised. The best way in which to avoid that kind of scenario is to limit access and exposure to the bacteria, especially when there are large amounts of it.

Guidance:

There are three recommended steps in addressing this question.

  1. To start, please list organisms you are using and organisms from which your parts are derived, indicating the risk group or biosafety level for each. For help, see Table 1 and 2 of the [http://www.who.int/csr/resources/publications/biosafety/Biosafety7.pdf World Health Organization (WHO) Laboratory Biosafety Manual]. You are welcome to use your national standards if you prefer. If national standards do not use the WHO 1-4 scale, please provide a link to an explanation of your standards.
  2. Then consider risks to team members, publics and environment if the project goes according to plan. Please describe risks posed by lab equipment and chemicals as well as biological parts and organisms. How are you addressing these issues in project design and lab work? Have you received biosafety training and other laboratory safety training? If so, please briefly describe the training.
  3. Then consider risks to team members, publics and environment if the project does not go according to plan. What are risks if safety measures such as containment procedures go wrong and organisms or parts are released? What are risks to security from malicious misuse? How are you addressing such risks?


2. Do any of the new BioBrick parts (or devices) that you made this year raise safety issues? If yes,

  • Did you document these issues in the Registry?
  • How did you manage to handle the safety issue?
  • How could other teams learn from your experience?
Guidance:

Please reference the biosafety level of parts. If you are working with anything other than a BSL1 organism, take extra care with this question. Your nation regulates handling and transfer of pathogens and parts associated with pathogenicity. For a list of regulated organisms, see the [http://www.australiagroup.net/en/biological_agents.html Australia Group website].


3. Is there a local biosafety group, committee, or review board at your institution?

  • If yes, what does your local biosafety group think about your project?
  • If no, which specific biosafety rules or guidelines do you have to consider in your country?
Guidance:

The iGEM Safety Committee is not a substitute for national and local university institional biosafety committees

  1. Does your university have a Biosafety Committee or equivalent? Please provide a link to regulations and local requirements.
  2. Is your project in compliance with national regulations and university requirements?
  3. If you are working with any organisms or parts requiring containment arrangements above BSL 1 or equivalent, have you consulted with your Institutional Biosafety Committee regarding your project?


4. Do you have any other ideas how to deal with safety issues that could be useful for future iGEM competitions? How could parts, devices and systems be made even safer through biosafety engineering?

Guidance:

This is an open-ended space for you to consider and suggest ways of improving safety or safety awareness at iGEM and beyond. Some iGEM teams have offered ideas (and sometimes full projects) to limit gene flow, to create software for screening pathogens, and to reduce reliance on antibiotic resistant markers. Other iGEM projects have discussed concerns that might arise if the project succeeded and became widely used, as commercial product or other means of distribution. Some iGEM projects have discussed risks that might materialize if the knowledge generated or methods developed were to become more widely available.

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